Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and there are currentl

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Use of lyophilized and acclimated digestate dominated by Methanobrevibacter as a start-up inoculum in anaerobic digester led to higher methane production in biochemical methane potential assays

Transporting wet inoculum for full-scale anaerobic digester (AD) start-up is usually infeasible and costly, especially, for remote locations.To overcome these burdens lyophilized AD inoculum is thought to be used after on-site acclimation.For this reason, in this study, the impact of three different acclimated lyophilized AD inoculums collected fro

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